Yes, it is prohibited to mix refrigerants. The correct move is to pull the charge and recharge it with whatever drop-in you are using. The real correct move is to fix the leak. After you mix it, at some point somebody is going to reclaim that refrigerant, and then they're going to have to pay to dispose of it because it is mixed refrigerant.
Request PDF | Mixtures to replace R22 in high-temperature heat pumps | This paper investigates various refrigerant mixtures to replace R22 that is currently used in several large (25MW) turbo However, it is suggested that if you do use an air conditioner that runs on R22, you should probably consider replacing it soon, or at least upgrading it to accept R410A refrigerant. At least this way, you are going to be protected should you be struggling to find R22. Can I Replace R22 with R410A? Not directly, no.
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R-22a is a hydrocarbon refrigerant blend with primary components including flammable substances such as propane and butane. In some cases, it may also contain small amounts of other hydrocarbons or a pine-scented odorant. This refrigerant is a highly flammable, colorless gas that is heavier than air. “R-22a” has been sold under the names

The aim of this paper is to determine the best available alternative which could replace existing refrigerant R22, with minimum or no changes in the air conditioning system. (35/65), R32/134A

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can i replace r22 with r32